Dissemin is shutting down on January 1st, 2025

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American Society of Hematology, Blood, 20(127), p. 2460-2471, 2016

DOI: 10.1182/blood-2015-10-675173

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Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis

Journal article published in 2016 by Christopher B. Hergott, Aoife M. Roche, Edwin Tamashiro, Thomas B. Clarke, Aubrey G. Bailey ORCID, Alice Laughlin, Frederic D. Bushman, Jeffrey N. Weiser
Distributing this paper is prohibited by the publisher
Distributing this paper is prohibited by the publisher

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Abstract

Key Points The intestinal microbiota regulates the steady-state survival and turnover kinetics of circulating neutrophils and inflammatory monocytes. The cytoplasmic peptido-glycan sensor Nod1 relays microbial signals into IL-17A–dependent stimulation of myeloid cell persistence.