This paper present the experiences gained from the study of ten up flow anaerobic sludge blanket (UASB) based sewage treatment plants (STPs) of different cities of India. Presently more than 23 UASB based STPs were under operation and about 20 UASB based STPs are under construction and commissioning phase at different towns. The nature of sewage significantly varied at each STP. Two STP were receiving sewage with high sulfate and heavy metals due to the mixing of industrial waste. The treatment performance of all UASB reactors in terms of BOD, COD and TSS were observed between 55 to 70% respectively. The post treatment units down flow hanging sponge (DHS) and Aeration followed by activated sludge process (ASP) at two STPs were performing well and enable to achieve the required disposal standards. Results indicate the effluent quality in terms of BOD and SS were less than 30 and 50 mg/L and well below the discharging standards.