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Wiley, Small, 10(7), p. 1416-1421, 2011

DOI: 10.1002/smll.201002298

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Bio-inspired micropatterned platform to steer stem cell differentiation

Journal article published in 2011 by Chor Yong Tay, Mintu Pal, Haiyang Yu ORCID, Wen Shing Leong, Nguan Soon Tan, Kee Woei Ng ORCID, Subbu Venkatraman, Freddy Boey, David Tai Leong, Lay Poh Tan
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Controlled stem cell differentiation on micropatterned biodegradable substrates involves modulation of the canonical FAK-ERK (focal adhesion kinase-extracellular-signal regulated kinase) signaling pathway in the absence of exogenous soluble factors. The use of a micropatterned platform to coerce human mesenchymal stem cells to adopt an elongated morphology bypasses the need to use pharmacological factors to repress FAK-ERK signaling activity to bring about substantial myogenesis.