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Impact Journals, Oncotarget, 6(5), p. 1576-1594, 2014

DOI: 10.18632/oncotarget.1738

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Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer

Journal article published in 2014 by Saverio Candido ORCID, Roberta Maestro, Jerry Polesel, Alessia Catania, Francesca Maira, Santo S. Signorelli, James A. McCubrey ORCID, Massimo Libra ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Cancer remains one of the major cause of death in the Western world. Although, it has been demonstrated that new therapies can improve the outcome of cancer patients, still many patients relapse after treatment. Therefore, there is a need to identify novel factors involved in cancer development and/or progression. Recently, neutrophil gelatinase-associated lipocalin (NGAL) has been suggested as a key player in different cancer types. Its oncogenic effect may be related to the complex NGAL/MMP-9. In the present study, NGAL was analyzed at both transcript and protein levels in different cancer types by analysing 38 public available microarray datasets and the Human Protein Atlas tool.