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American Society of Hematology, Blood, 18(127), p. 2231-2240, 2016

DOI: 10.1182/blood-2015-09-670208

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Aryl hydrocarbon receptor-dependent enrichment of a megakaryocytic precursor with a high potential to produce proplatelets

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Data provided by SHERPA/RoMEO

Abstract

Key Points Emergence of a CD34+CD41low population with a high capacity to generate proplatelet-producing MKs and functional platelet-like elements. Platelet production is inversely correlated to CYP1B1 expression, a target of the aryl hydrocarbon receptor.