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American Thoracic Society, American Journal of Respiratory and Critical Care Medicine, 6(156), p. 1794-1799, 1997

DOI: 10.1164/ajrccm.156.6.9706026

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Enhanced Thromboxane Biosynthesis in Patients with Chronic Obstructive Pulmonary Disease

Journal article published in 1997 by Giovanni Davì, Stefania Basili, Mario Vieri, Francesco Cipollone, Stella Santarone, Cesare Alessandri, Pierpaolo P. Gazzaniga, N. De Luca, Corrado Cordova, L. Coppotelli, Gazzaniga Pp, Francesco Violi ORCID, M. Paradiso, A. Bellomo, A. Belogi and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Thrombotic complications of pulmonary circulation occur in patients with chronic obstructive pulmonary disease (COPD). In the present study, we sought to evaluate in vivo platelet activation through the measurement of 11/dehydro-thromboxane (Tx) B2 TxA2 major metabolite in the urine, in 29 patients with COPD, compared with 29 sex- and age-matched healthy subjects. The urinary excretion of 11-dehydro-TxB2 was significantly higher in patients with COPD than in control subjects: median (range), 753 (277-4,409) and 275 (129-612) pg/mg creatinine, respectively; p