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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 5(60), p. 3202-3206, 2016

DOI: 10.1128/aac.00152-16

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Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis

Journal article published in 2016 by Gaëlle Guiewi Makafe, Yuanyuan Cao, Yaoju Tan, Mugweru Julius, Zhiyong Liu, Changwei Wang, Moses M. Njire, Xingshan Cai, Tianzhou Liu, Bangxing Wang, Wei Pang, Shouyong Tan, Buchang Zhang, Wing Wai Yew, Gyanu Lamichhane ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We expressed the wild-type rplC and mutated rplC (Cys154Arg) genes, respectively, in Mycobacterium tuberculosis H37Ra and H37Rv in an attempt to delineate the role of rplC (Cys154Arg) regarding oxazolidinone resistance. An increase of the MICs of linezolid (LZD) and sutezolid (PNU-100480, PNU) against the recombinant mycobacteria with overexpressed rplC mutation (Cys154Arg) was found, suggesting the rplC gene is a determinant of bacillary susceptibilities to LZD and PNU.