We analyzed a photon detector for positron emission tomography with high spatial resolution and depth of interaction capability. The detector is composed of a monolithic LYSO scintillator crystal coupled on top and bottom sides to two custom SiPM arrays. We investigated the ability to reconstruct the DOI of the 511 keV photon comparing the number of triggered SiPMs on the two sides of the module. Acquisitions were performed scanning the lateral surface of the crystal with a collimated 511 keV photon beam at different incident positions. A standard deviation of 1.5 mm in depth of interaction was obtained at the center of the module.