Oxford University Press, Journal of Pharmacy and Pharmacology, 2(48), p. 210-213, 1996
DOI: 10.1111/j.2042-7158.1996.tb07125.x
Full text: Unavailable
Abstract A series of bicyclic analogues incorporating the homocholine motif of methyllycaconitine has been prepared to test the hypothesis that this is the essential pharmacophore of this potent, selective nicotinic receptor antagonist. A double Mannich reaction has been employed to construct the 3-azabicyclo[3.3.1]-nonane ring system, containing an N-ethylpiperidine moiety. The neopentyl-like alcohol was then esterified, using isatoic anhydride under basic conditions, to afford the corresponding anthranilate.