Published in

Elsevier, Annals of Oncology, 9(23), p. 2362-2374, 2012

DOI: 10.1093/annonc/mds171

Links

Tools

Export citation

Search in Google Scholar

Menstrual and reproductive factors, and hormonal contraception use: associations with non-Hodgkin lymphoma in a pooled analysis of InterLymph case–control studies

Journal article published in 2012 by E. V. Kane, E. Roman, N. Becker, L. Bernstein, P. Boffetta, P. M. Bracci, J. R. Cerhan, B. C.-H. Chiu, P. Cocco, L. Costas ORCID, L. Foretova, E. A. Holly, C. La Vecchia, K. Matsuo, M. Maynadie and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Kane, E V Roman, E Becker, N Bernstein, L Boffetta, P Bracci, P M Cerhan, J R Chiu, B C-H Cocco, P Costas, L Foretova, L Holly, E A La Vecchia, C Matsuo, K Maynadie, M Sanjose, S Spinelli, J J Staines, A Talamini, R Wang, S S Zhang, Y Zheng, T Kricker, A eng CA143947/CA/NCI NIH HHS/ CA150037/CA/NCI NIH HHS/ CA45614/CA/NCI NIH HHS/ CA50850/CA/NCI NIH HHS/ CA62006/CA/NCI NIH HHS/ CA87014/CA/NCI NIH HHS/ CA89745/CA/NCI NIH HHS/ CA92153/CA/NCI NIH HHS/ CA97274/CA/NCI NIH HHS/ PC65064/PC/NCI NIH HHS/ PC67008/PC/NCI NIH HHS/ PC67009/PC/NCI NIH HHS/ PC67010/PC/NCI NIH HHS/ PC71105/PC/NCI NIH HHS/ Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2012/07/13 06:00 Ann Oncol. 2012 Sep;23(9):2362-74. Epub 2012 Jul 10. ; International audience ; BACKGROUND: The two most common forms of non-Hodgkin lymphoma (NHL) exhibit different sex ratios: diffuse large B-cell lymphoma (DLBCL) occurs more frequently in men and follicular lymphoma (FL) more frequently in women. Looking among women alone, this pooled analysis explores the relationship between reproductive histories and these cancers. MATERIALS AND METHODS: Self-reported reproductive histories from 4263 women with NHL and 5971 women without NHL were pooled across 18 case-control studies (1983-2005) from North America, Europe and Japan. Study-specific odd ratios (ORs) and confidence intervals (CIs) were estimated using logistic regression and pooled using random-effects meta-analyses. RESULTS: Associations with reproductive factors were found for FL rather than NHL overall and DLBCL. In particular, the risk of FL decreased with increasing number of pregnancies (pooled OR(trend) = 0.88, 95% CI 0.81-0.96). FL was associated with hormonal contraception (pooled OR = 1.30, 95% CI 1.04-1.63), and risks were increased when use started after the age of 21, was used for 20 years before diagnosis. DLBCL, on the other hand, was not associated with hormonal contraception (pooled OR = 0.87, 95% CI 0.65-1.16). CONCLUSIONS: Hormonal contraception is associated with an increased risk of FL but not of DLBCL or NHL overall.