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Public Library of Science, PLoS ONE, 3(10), p. e0119459, 2015

DOI: 10.1371/journal.pone.0119459

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Association Studies of Calcium-Sensing Receptor (CaSR) Polymorphisms with Serum Concentrations of Glucose and Phosphate, and Vascular Calcification in Renal Transplant Recipients

Journal article published in 2015 by Valerie N. Babinsky, Fadil M. Hannan, Sonia C. Youhanna, Céline Maréchal, Michel Jadoul, Olivier Devuyst, Rajesh V. Thakker ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Cardiovascular disease is the major cause of death in renal transplant recipients (RTRs) and linked to arterial calcification. The calcium-sensing receptor (CaSR), a G-protein coupled receptor, plays a pivotal role in extracellular calcium homeostasis and is expressed in the intimal and medial layers of the arterial wall. We investigated whether common CASR gene variants are predictors for aortic and coronary artery calcification or influence risk factors such as serum calcium, phosphate and glucose concentrations in RTRs.