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Bentham Science Publishers, Current Neuropharmacology, 3(8), p. 182-193

DOI: 10.2174/157015910792246245

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The Role of Mitochondria in Brain Aging and the Effects of Melatonin

Journal article published in 2010 by Luis Carlos López, Germaine Escames, Ana López, Jose Antonio Garcia, José Antonio García, Laura Garcia, Laura García, Darío Acuña-Castroviejo ORCID, José Joaquín García, Luis Carlos Lopez
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Melatonin is an endogenous indoleamine present in different tissues, cellular compartments and organelles including mitochondria. When melatonin is administered orally, it is readily available to the brain where it counteracts different processes that occur during aging and age-related neurodegenerative disorders. These aging processes include oxidative stress and oxidative damage, chronic and acute inflammation, mitochondrial dysfunction and loss of neural regeneration. This review summarizes age related changes in the brain and the importance of oxidative/nitrosative stress and mitochondrial dysfunction in brain aging. The data and mechanisms of action of melatonin in relation to aging of the brain are reviewed as well.