American Association for the Advancement of Science, Science, 6141(341), 2013
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Genetic Mosaicism in Brain Development With the increased power now available in sequencing and genomic technologies has come the realization that within an organism, individual cellular genomes can diverge from one another. Poduri et al. (p. 10.1126/science.1237758 ) review how de novo mutations, which arise in the parental germ line, or during development of the child, are the cause of a variety of neurodevelopmental disorders.