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Oxford University Press, The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 5(60), p. 574-587, 2005

DOI: 10.1093/gerona/60.5.574

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Disentangling the Genetic Determinants of Human Aging: Biological Age as an Alternative to the Use of Survival Measures

Journal article published in 2005 by David Karasik, Serkalem Demissie, L. Adrienne Cupples, Douglas P. Kiel ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The choice of a phenotype is critical for the study of a complex genetically regulated process, such as aging. To date, most of the twin and family studies have focused on broad survival measures, primarily age at death or exceptional longevity. However, on the basis of recent studies of twins and families, biological age has also been shown to have a strong genetic component, with heritability estimates ranging from 27% to 57%. The aim of this review is twofold: first, to summarize growing consensus on reliable methods of biological age assessment, and second, to demonstrate validity of this phenotype for research in the genetics of aging in humans.