Published in
American Society for Microbiology, Journal of Bacteriology, 10(193), p. 2647-2651, 2011
DOI: 10.1128/jb.00108-11
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Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin in Streptomyces lydicus: Tailoring Modification of 3-Methyl-Aspartate
Journal article published in 2011 by
Dina H. Horna,
Cristina Gómez,
Carlos Olano,
Martina Palomino-Schätzlein 
,
Antonio Pineda-Lucena,
Rodrigo J. Carbajo,
Alfredo F. Braña,
Carmen Méndez,
José A. Salas
,
Antonio Pineda-Lucena,
Rodrigo J. Carbajo,
Alfredo F. Braña,
Carmen Méndez,
José A. Salas
This paper is made freely available by the publisher.
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Abstract
ABSTRACT The asparaginyl-tRNA synthetase-like SlgZ and methyltransferase SlgM enzymes are involved in the biosynthesis of the tetramic acid streptolydigin in Streptomyces lydicus . Inactivation of slgZ led to a novel streptolydigin derivative. Overexpression of slgZ , slgM , or both in S. lydicus led to a considerable increase in streptolydigin production.