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Cell Press, Cancer Cell, 6(14), p. 431-433, 2008

DOI: 10.1016/j.ccr.2008.11.011

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The aneuploidy paradox in cell growth and tumorigenesis

Journal article published in 2008 by Beth A. Weaver, Don W. Cleveland ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Aneuploidy, an abnormal chromosome number, is a frequent characteristic of malignant cells, leading to the suggestion that aneuploidy drives tumorigenesis. In a recent issue of Science, Williams et al. identified a paradoxical relationship between aneuploidy and its linkage to tumorigenesis: chromosome gains in nontransformed cells are antiproliferative, despite frequently occurring in human tumors.