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Springer, Photochemical & Photobiological Sciences, 5(10), p. 751-758, 2011

DOI: 10.1039/c0pp00345j

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The immunosuppressive side of PDT†

Journal article published in 2011 by Pawel Mroz, Michael R. Hamblin ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Photodynamic therapy (PDT) is a promising novel therapeutic procedure for the management of a variety of solid tumors and many non-malignant diseases. PDT has been described as having a significant effect on the immune system, which may be either immunostimulatory or, in some circumstances, immunosuppressive. The immunosuppressive effects of PDT have nearly all been concerned with the suppression of the contact hypersensitivity reaction in mice. Here, we review the immunosuppressive aspects of PDT treatment and discuss some additional mechanisms that may be involved.