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Public Library of Science, PLoS ONE, 1(7), p. e29408, 2012

DOI: 10.1371/journal.pone.0029408

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Highly Dynamic Host Actin Reorganization around Developing Plasmodium Inside Hepatocytes

Journal article published in 2012 by Carina S. S. Gomes-Santos, Maurice A. Itoe, Cristina Afonso, Ricardo Henriques, Rui Gardner, Nuno Sepúlveda, Pedro D. Simões, Helena Raquel, António Paulo Almeida, Luis F. Moita ORCID, Friedrich Frischknecht, Maria Mm Mota
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around developing Plasmodium berghei parasites inside human hepatoma cells. Actin reorganization is most prominent between 10 to 16 hours post infection and depends on the actin severing and capping protein, gelsolin. Live cell imaging studies also suggest that the hepatocyte cytoskeleton may contribute to parasite elimination during Plasmodium development in the liver.