I review recently completed (since Lattice 2013) and ongoing lattice calculations in charm and bottom flavor physics. A comparison of the precision of lattice and experiment is made using both current experimental results and projected experimental precision in 2020. The combination of experiment and theory reveals several tensions between nature and the Standard Model. These tensions are reviewed in light of recent lattice results. ; Comment: 18 pages, 9 figures; Review at The 32nd International Symposium on Lattice Field Theory, 23-28 June, 2014, Columbia University New York, NY; PoS(LATTICE2014)002: Ver. 2 fixes several several typos, including labels in Fig. 3 and updates references, including the addition of recent results to Figs. 7 and 8