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Elsevier, Journal of Infection, 6(70), p. 616-623, 2015

DOI: 10.1016/j.jinf.2014.10.011

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Delayed reconstitution of B cell immunity to pneumococcus in HIV-infected Malawian children on antiretroviral therapy

Journal article published in 2015 by Oluwadamilola H. Iwajomo, Peter Moons, Rose Nkhata, David Mzinza ORCID, Abiodun D. Ogunniyi, Neil A. Williams, Robert S. Heyderman, Adam Finn
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Despite CD4(+) count restoration and viral load suppression with antiretroviral therapy (ART), HIV-infected children remain at increased risk of life-threatening infections including invasive pneumococcal disease (IPD). We therefore investigated whether persistent susceptibility to IPD following ART is associated with incomplete recovery of B-cell function.