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Elsevier, Journal of Biological Chemistry, 27(285), p. 20492-20498, 2010

DOI: 10.1074/jbc.m110.102111

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IL-10 Inhibits miR-155 Induction by Toll-like Receptors*

Journal article published in 2010 by Claire E. McCoy ORCID, Frederick J. Sheedy, Joseph E. Qualls, Sarah L. Doyle, Susan R. Quinn, Peter J. Murray, Luke A. J. O'Neill
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

IL-10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes, which are induced by Toll-like receptor (TLR) signaling. In this study, we have examined whether modulation of microRNAs plays a role in the inhibitory effect of IL-10 on TLR4 signaling. Analyzing microRNAs known to be induced by TLR4, we found that IL-10 could inhibit the expression of miR-155 in response to lipopolysaccharide but had no effect on miR-21 or miR-146a. IL-10 inhibited miR-155 transcription from the BIC gene in a STAT3-dependent manner. This inhibitory effect of IL-10 on miR-155 led to an increase in the expression of the miR-155 target, SHIP1. This is the first example of IL-10 playing a role in microRNA function and suggests that through its inhibitory effect on miR-155, IL-10 has the ability to promote anti-inflammatory gene expression.