Prior research found reduced mortality in coronary heart patients with higher scores on the Openness to Experience (O) domain and its facets. Decreased C-reactive protein level (CRP) levels may be one mechanism by which higher O leads to decreased mortality. Thus, the current study aimed to test the association between the O domain and its facets, as assessed by the NEO Personality Inventory-Revised, and CRP in a sample of 165 healthy black and white, male and female community volunteers.