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Elsevier, Journal of Biological Chemistry, 16(286), p. 13801-13804, 2011

DOI: 10.1074/jbc.c111.229096

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The Anti-angiogenic Peptide Anginex Greatly Enhances Galectin-1 Binding Affinity for Glycoproteins*

Journal article published in 2011 by Emma Salomonsson, Victor L. Thijssen, Arjan W. Griffioen, Ulf J. Nilsson ORCID, Hakon Leffler
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Angiogenesis is a key event in cancer progression and therefore a promising target in cancer treatment. Galectin-1, a β-galactoside binding lectin, is up-regulated in the endothelium of tumors of different origin and has been shown to be the target for anginex, a powerful anti-angiogenic peptide with anti-tumor activity. Here we show that when bound to anginex, galectin-1 binds various glycoproteins with hundred- to thousand-fold higher affinity. Anginex also interacts with galectin-2, -7, -8N, and -9N but not with galectin-3, -4, or -9C.