Abstract Purpose: To describe the retinal changes occurring after Ozurdex(®) (Ozurdex, Allergan, Inc., Irvine, CA) injection and peripheral laser treatment in a case of central retinal vein occlusion (CRVO). Case Report: A 51-year-old Caucasian man with massive retinal edema (926 μm) and hand motion visual acuity due to severe CRVO was treated early with Ozurdex intravitreal injection. Detailed monthly follow-up examinations showed complete resorption of the edema (253 μm) after 2 months and a 20/32 visual outcome after 3 months. The patient subsequently developed peripheral retinal ischemia accompanied by recurrence of small retinal cystoid spaces (295 μm); therefore, he underwent an associated laser treatment on the involved peripheral retina, which led to a recovery in retinal thickness (280 μm). His visual acuity remained stable at 20/32. Conclusions: Early Ozurdex injection in association with late laser photocoagulation was effective in the resorption of CRVO macular edema and in restoring reasonably good visual acuity.