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American Society for Microbiology, Journal of Virology, 23(85), p. 12804-12810, 2011

DOI: 10.1128/jvi.05841-11

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CD8<sup>+</sup>T Cell Escape Mutations in Simian Immunodeficiency Virus SIVmac239 Cause Fitness DefectsIn Vivo, and Many Revert after Transmission

Journal article published in 2011 by Philip A. Mudd ORCID, Adam J. Ericsen, Andrew D. Walsh, Enrique J. León, Nancy A. Wilson ORCID, Nicholas J. Maness, Thomas C. Friedrich, David I. Watkins
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Virus-specific CD8 + T lymphocytes select for escape mutations in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). To assess the effects of these mutations on viral fitness, we introduced escape mutations into 30 epitopes (bound by five major histocompatibility complex class I [MHC-I] molecules) in three different viruses. Two of these MHC-I alleles are associated with elite control. Two of the three viruses demonstrated reduced fitness in vivo , and 27% of the introduced mutations reverted. These findings suggest that T cell epitope diversity may not be such a daunting problem for the development of an HIV vaccine.