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Bohn Stafleu van Loghum, Critical Care, 1(14), p. R5

DOI: 10.1186/cc8844

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Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial

Journal article published in 2010 by Vera M. Barbosa, Elizabeth A. Miles ORCID, Conceição Calhau, Estevão Lafuente, Philip C. Calder
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Introduction: the effect of parenteral fish oil in septic patients is not widely studied. This study investigated the effects of parenteral fish oil on plasma phospholipid fatty acids, inflammatory mediators, and clinical outcomes. Methods: twenty-five patients with systemic inflammatory response syndrome or sepsis, and predicted to need parenteral nutrition were randomized to receive either a 50:50 mixture of medium-chain fatty acids and soybean oil or a 50:40:10 mixture of medium-chain fatty acids, soybean oil and fish oil. Parenteral nutrition was administrated continuously for five days from admission. Cytokines and eicosanoids were measured in plasma and in lipopolysaccharide-stimulated whole blood culture supernatants. Fatty acids were measured in plasma phosphatidylcholine. Results: fish oil increased eicosapentaenoic acid in plasma phosphatidylcholine (P