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Wiley Open Access, FEBS Open Bio, 1(4), p. 377-386, 2014

DOI: 10.1016/j.fob.2014.03.013

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Fructose 1-phosphate is the one and only physiological effector of the Cra (FruR) regulator ofPseudomonas putida

Journal article published in 2014 by Max Chavarría ORCID, Gonzalo Durante-Rodríguez, Tino Krell, César Santiago, Jan Brezovsky, Jiri Damborsky, Víctor de Lorenzo
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

•The role of FBP as effector of the Cra protein of soil bacterium Pseudomonas putida is unclear.•Biochemical, biophysical and genetic data show that Cra binds only F1P as metabolic agonist.•F1P is the only physiological effector of the Cra protein of P. putida in vivo.•This regulatory exaptation of Cra exemplifies how transcriptional factors can diversify in bacteria.