Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.

Ösby, Urban; Sklar, Pamela; Þorgeirsson, Þorgeir; Ripke, Stephan; Scott, Laura J.; Andreassen, Ole A.; Cichon, Sven; Craddock, Nick; Thornorgeirsson, Thornorgeir; Edenberg, Howard J.; Nurnberger, John I.; Rietschel, Marcella; Blackwood, Douglas; Corvin, Aiden; Flickinger, Matthew; Guan, Weihua; Mattingsdal, Morten; Wienker, Thomas F.; McQuillin, Andrew; Kwan, Phoenix; Daly, Mark; Dudbridge, Frank; Holmans, Peter A.; Lin, Danyu; Burmeister, Margit; Zoellner, Sebastian; Greenwood, Tiffany A.; Hamshere, Marian L.; Zandi, Peter Pp; Muglia, Pierandrea; Smith, Erin N.; Nievergelt, Caroline M.; McKinney, Rebecca; Shilling, Paul D.; Schork, Nicholas J.; Bloss, Cinnamon S.; Foroud, Tatiana; Koller, Daniel L.; Gershon, Elliot S.; Liu, Chunyu; Badner, Judith A.; Scheftner, William A.; Lawson, William B.; Nwulia, Evaristus A.; Hipolito, Maria; Coryell, William; Rice, John P.; Byerley, William; Zöllner, Sebastian; McMahon, Francis J.; Schulze, Thomas G.; Berrettini, Wade; Zhang, Peng; Lohoff, Falk W.; Potash, James B.; Mcinnis, Melvin G.; Szelinger, Szabocls; Mahon, Pamela B.; McInnis, Mg G.; Craig, David W.; Witt, Stephanie H.; Barrett, Thomas B.; Tozzi, Federica; Breuer, René; Meier, Sandra; Strohmaier, Jana; Xu, Wei; Ferreira, Manuel D. C.; Farmer, Anne; McGuffin, Peter; Vincent, John B.; Strauss, John; Kennedy, James L.; Matthews, Keith; Day, Richard; Ferreira, Manuel A.; O'Dushlaine, Colm; Perlis, Roy; Raychaudhuri, Soumya; Lee, Phil H.; Ruderfer, Douglas; Smoller, Jordan W.; Hyoun, Phil L.; Li, Jun; Absher, Devin; Thompson, Robert C.; Bunney, William E.; Watson, Stanley J.; Barchas, Jack D.; Schatzberg, Alan F.; Muhleisen, Tw W.; Jones, Edward G.; Meng, Fan Guo; Nöthen, Markus M.; Myers, Richard M.; Akil, Huda; Boehnke, Michael; Chambert, Kim; Moran, Jennifer; Scolnick, Ed; Djurovic, Srdjan; Melle, Ingrid; Morken, Gunnar; Gill, Michael; Morris, Derek; Muehleisen, Thomas W.; Quinn, Emma; Mühleisen, Thomas W.; Noethen, Markus M.; Degenhardt, Franziska A.; Mattheisen, Manuel; Schumacher, Johannes; Mclean, Alan W.; Maier, Wolfgang; Steffens, Michael; Propping, Peter; Nöthen, Markus M.; Anjorin, Adebayo; Bass, Nick; Gurling, Hugh; Kandaswamy, Radhika; Lawrence, Jacob; McLean, Aw W.; McGhee, Kevin; McIntosh, Andrew; Muir, Walter J.; St Clair, David; Pickard, Benjamin S.; Breen, Gerome; O’Donovan, Michael; Caesar, Sian; Gordon-Smith, Katherine; Jones, Lisa; Fraser, Christine; Green, Elaine K.; Grozeva, Detelina; Williamson, Richard; Jones, Ian R.; Young, Allan H.; Kirov, George; Moskvina, Valentina; Nikolov, Ivan; Nicol Ferrier, I.; O'Donovan, Michael C.; Owen, Michael J.; Collier, David A.; Elkin, Amanda; Ferrier, In Nicol; Stefansson, Kari; Porgeirsson, Porgeir; Stefansson, Hreinn; Steinberg, Stacy; Gustafsson, Omar; Gustafsson, Ó.; Bergen, Sarah E.; Nimgaonkar, Vishwajit; Hultman, Christina; Sigur Sson, Engilbert; Landén, Mikael; Lichtenstein, Paul; Sullivan, Patrick; Óskarsson, Högni; Schalling, Martin; Osby, Urban; Backlund, Lena; Frisén, Louise; Langstrom, Niklas; Sigurosson, Engilbert; Jamain, Stéphane; Leboyer, Marion; Etain, Bruno; Muller-Mysok, B.; Bellivier, Frank; Petursson, Hannes; Sigur∂sson, Engilbert; Sigurdsson, E.; Mueller-Mysok, Bertram; Müller-Mysok, Bertram; Wright, Adam; Lucae, Susanne; Schwarz, Markus; Fullerton, Janice M.; Schofield, Peter R.; Martin, Nick; Montgomery, Grant W.; Lathrop, Mark; Oskarsson, Högni; Bauer, Michael; Mitchell, Philip B.; Hautzinger, Martin; Reif, Andreas; Kelsoe, John R.; Psychiat Gwas Consortium Bipolar, D.; Purcell, Shaun M.; Swami, Meera

Dissemin
Ole A. Andreassen
Ösby et al., 2011

Published in

Nature Research, Nature Medicine, 10(17), p. 1199-1199, 2011

DOI: 10.1038/nm.2524

Nature Research, Nature Genetics, 10(43), p. 977-983

DOI: 10.1038/ng.943

Tools

Export citation

Format

@article{Ösby2011,
  abstract = {We conducted a combined genome-wide association study (GWAS) of 7,481 individuals with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS Consortium. Our replication study tested 34 SNPs in 4,496 independent cases with bipolar disorder and 42,422 independent controls and found that 18 of 34 SNPs had P &lt; 0.05, with 31 of 34 SNPs having signals with the same direction of effect (P = 3.8 x 10(-7)). An analysis of all 11,974 bipolar disorder cases and 51,792 controls confirmed genome-wide significant evidence of association for CACNA1C and identified a new intronic variant in ODZ4. We identified a pathway comprised of subunits of calcium channels enriched in bipolar disorder association intervals. Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4. Our replication results imply that increasing sample sizes in bipolar disorder will confirm many additional loci.},
  author = {Ösby, Urban and Sklar, Pamela and Þorgeirsson, Þorgeir and Ripke, Stephan and Scott, Laura J. and Andreassen, Ole A. and Cichon, Sven and Craddock, Nick and Thornorgeirsson, Thornorgeir and Edenberg, Howard J. and Nurnberger, John I. and Rietschel, Marcella and Blackwood, Douglas and Corvin, Aiden and Flickinger, Matthew and Guan, Weihua and Mattingsdal, Morten and Wienker, Thomas F. and McQuillin, Andrew and Kwan, Phoenix and Daly, Mark and Dudbridge, Frank and Holmans, Peter A. and Lin, Danyu and Burmeister, Margit and Zoellner, Sebastian and Greenwood, Tiffany A. and Hamshere, Marian L. and Zandi, Peter Pp and Muglia, Pierandrea and Smith, Erin N. and Nievergelt, Caroline M. and McKinney, Rebecca and Shilling, Paul D. and Schork, Nicholas J. and Bloss, Cinnamon S. and Foroud, Tatiana and Koller, Daniel L. and Gershon, Elliot S. and Liu, Chunyu and Badner, Judith A. and Scheftner, William A. and Lawson, William B. and Nwulia, Evaristus A. and Hipolito, Maria and Coryell, William and Rice, John P. and Byerley, William and Zöllner, Sebastian and McMahon, Francis J. and Schulze, Thomas G. and Berrettini, Wade and Zhang, Peng and Lohoff, Falk W. and Potash, James B. and Mcinnis, Melvin G. and Szelinger, Szabocls and Mahon, Pamela B. and McInnis, Mg G. and Craig, David W. and Witt, Stephanie H. and Barrett, Thomas B. and Tozzi, Federica and Breuer, René and Meier, Sandra and Strohmaier, Jana and Xu, Wei and Ferreira, Manuel D. C. and Farmer, Anne and McGuffin, Peter and Vincent, John B. and Strauss, John and Kennedy, James L. and Matthews, Keith and Day, Richard and Ferreira, Manuel A. and O'Dushlaine, Colm and Perlis, Roy and Raychaudhuri, Soumya and Lee, Phil H. and Ruderfer, Douglas and Smoller, Jordan W. and Hyoun, Phil L. and Li, Jun and Absher, Devin and Thompson, Robert C. and Bunney, William E. and Watson, Stanley J. and Barchas, Jack D. and Schatzberg, Alan F. and Muhleisen, Tw W. and Jones, Edward G. and Meng, Fan Guo and Nöthen, Markus M. and Myers, Richard M. and Akil, Huda and Boehnke, Michael and Chambert, Kim and Moran, Jennifer and Scolnick, Ed and Djurovic, Srdjan and Melle, Ingrid and Morken, Gunnar and Gill, Michael and Morris, Derek and Muehleisen, Thomas W. and Quinn, Emma and Mühleisen, Thomas W. and Noethen, Markus M. and Degenhardt, Franziska A. and Mattheisen, Manuel and Schumacher, Johannes and Mclean, Alan W. and Maier, Wolfgang and Steffens, Michael and Propping, Peter and Nöthen, Markus M. and Anjorin, Adebayo and Bass, Nick and Gurling, Hugh and Kandaswamy, Radhika and Lawrence, Jacob and McLean, Aw W. and McGhee, Kevin and McIntosh, Andrew and Muir, Walter J. and St Clair, David and Pickard, Benjamin S. and Breen, Gerome and O’Donovan, Michael and Caesar, Sian and Gordon-Smith, Katherine and Jones, Lisa and Fraser, Christine and Green, Elaine K. and Grozeva, Detelina and Williamson, Richard and Jones, Ian R. and Young, Allan H. and Kirov, George and Moskvina, Valentina and Nikolov, Ivan and Nicol Ferrier, I. and O'Donovan, Michael C. and Owen, Michael J. and Collier, David A. and Elkin, Amanda and Ferrier, In Nicol and Stefansson, Kari and Porgeirsson, Porgeir and Stefansson, Hreinn and Steinberg, Stacy and Gustafsson, Omar and Gustafsson, Ó. and Bergen, Sarah E. and Nimgaonkar, Vishwajit and Hultman, Christina and Sigur Sson, Engilbert and Landén, Mikael and Lichtenstein, Paul and Sullivan, Patrick and Óskarsson, Högni and Schalling, Martin and Osby, Urban and Backlund, Lena and Frisén, Louise and Langstrom, Niklas and Sigurosson, Engilbert and Jamain, Stéphane and Leboyer, Marion and Etain, Bruno and Muller-Mysok, B. and Bellivier, Frank and Petursson, Hannes and Sigur∂sson, Engilbert and Sigurdsson, E. and Mueller-Mysok, Bertram and Müller-Mysok, Bertram and Wright, Adam and Lucae, Susanne and Schwarz, Markus and Fullerton, Janice M. and Schofield, Peter R. and Martin, Nick and Montgomery, Grant W. and Lathrop, Mark and Oskarsson, Högni and Bauer, Michael and Mitchell, Philip B. and Hautzinger, Martin and Reif, Andreas and Kelsoe, John R. and Psychiat Gwas Consortium Bipolar, D. and Purcell, Shaun M. and Swami, Meera},
  doi = {10.1038/nm.2524},
  journal = {Nature Genetics},
  month = {sep},
  pages = {977-983},
  title = {Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.},
  url = {https://www.nature.com/articles/ng.943.pdf},
  volume = {43},
  year = {2011}
}

Download

Export citation

Search in Google Scholar

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.

Journal article published in 2011 by Urban Ösby, Pamela Sklar, Þorgeir Þorgeirsson, Stephan Ripke, Laura J. Scott, Ole A. Andreassen

, Sven Cichon, Nick Craddock, Thornorgeir Thornorgeirsson, Howard J. Edenberg

, John I. Nurnberger, Marcella Rietschel, Douglas Blackwood, Aiden Corvin, Matthew Flickinger and other authors. Urban Ösby, Pamela Sklar, Þorgeir Þorgeirsson, Stephan Ripke, Laura J. Scott, Ole A. Andreassen

, Sven Cichon, Nick Craddock, Thornorgeir Thornorgeirsson, Howard J. Edenberg

, John I. Nurnberger, Marcella Rietschel, Douglas Blackwood, Aiden Corvin, Matthew Flickinger, Weihua Guan, Morten Mattingsdal, Thomas F. Wienker, Andrew McQuillin, Phoenix Kwan, Mark Daly, Frank Dudbridge, Peter A. Holmans, Danyu Lin, Margit Burmeister, Sebastian Zoellner, Tiffany A. Greenwood, Marian L. Hamshere, Peter Pp Zandi, Pierandrea Muglia

, Erin N. Smith, Caroline M. Nievergelt

, Rebecca McKinney, Paul D. Shilling, Nicholas J. Schork, Cinnamon S. Bloss, Tatiana Foroud, Daniel L. Koller, Elliot S. Gershon, Chunyu Liu, Judith A. Badner, William A. Scheftner, William B. Lawson, Evaristus A. Nwulia, Maria Hipolito, William Coryell, John P. Rice, William Byerley, Sebastian Zöllner, Francis J. McMahon

, Thomas G. Schulze, Wade Berrettini, Peng Zhang, Falk W. Lohoff, James B. Potash, Melvin G. Mcinnis, Szabocls Szelinger, Pamela B. Mahon, Mg G. McInnis, David W. Craig, Stephanie H. Witt, Thomas B. Barrett, Federica Tozzi, René Breuer, Sandra Meier, Jana Strohmaier, Wei Xu, Manuel D. C. Ferreira, Anne Farmer, Peter McGuffin, John B. Vincent, John Strauss, James L. Kennedy, Keith Matthews, Richard Day, Manuel A. Ferreira, Colm O'Dushlaine, Roy Perlis, Soumya Raychaudhuri, Phil H. Lee, Douglas Ruderfer

, Jordan W. Smoller, Phil L. Hyoun, Jun Li, Devin Absher, Robert C. Thompson, William E. Bunney, Stanley J. Watson, Jack D. Barchas, Alan F. Schatzberg, Tw W. Muhleisen, Edward G. Jones, Fan Guo Meng, Markus M. Nöthen, Richard M. Myers, Huda Akil, Michael Boehnke, Kim Chambert, Jennifer Moran, Ed Scolnick, Srdjan Djurovic, Ingrid Melle, Gunnar Morken, Michael Gill, Derek Morris

, Thomas W. Muehleisen, Emma Quinn, Thomas W. Mühleisen, Markus M. Noethen, Franziska A. Degenhardt, Manuel Mattheisen

, Johannes Schumacher, Alan W. Mclean, Wolfgang Maier, Michael Steffens, Peter Propping, Markus M. Nöthen, Adebayo Anjorin, Nick Bass, Hugh Gurling, Radhika Kandaswamy, Jacob Lawrence, Aw W. McLean, Kevin McGhee, Andrew McIntosh

, Walter J. Muir, David St Clair, Benjamin S. Pickard, Gerome Breen

, Michael O’Donovan, Sian Caesar, Katherine Gordon-Smith, Lisa Jones, Christine Fraser, Elaine K. Green, Detelina Grozeva, Richard Williamson, Ian R. Jones, Allan H. Young, George Kirov, Valentina Moskvina, Ivan Nikolov, I. Nicol Ferrier, Michael C. O'Donovan

, Michael J. Owen, David A. Collier, Amanda Elkin, In Nicol Ferrier, Kari Stefansson, Porgeir Porgeirsson, Hreinn Stefansson, Stacy Steinberg, Omar Gustafsson, Ó. Gustafsson, Sarah E. Bergen, Vishwajit Nimgaonkar, Christina Hultman, Engilbert Sigur Sson, Mikael Landén, Paul Lichtenstein, Patrick Sullivan, Högni Óskarsson, Martin Schalling, Urban Osby, Lena Backlund, Louise Frisén, Niklas Langstrom, Engilbert Sigurosson, Stéphane Jamain, Marion Leboyer, Bruno Etain, B. Muller-Mysok, Frank Bellivier, Hannes Petursson, Engilbert Sigur∂sson, E. Sigurdsson, Bertram Mueller-Mysok, Bertram Müller-Mysok, Adam Wright, Susanne Lucae, Markus Schwarz, Janice M. Fullerton, Peter R. Schofield

, Nick Martin, Grant W. Montgomery, Mark Lathrop, Högni Oskarsson, Michael Bauer, Philip B. Mitchell, Martin Hautzinger, Andreas Reif, John R. Kelsoe, D. Psychiat Gwas Consortium Bipolar, Shaun M. Purcell, Meera Swami

Show less

This paper is made freely available by the publisher.

Full text: Download

Preprint: archiving allowed

Upload

Postprint: archiving restricted

Upload

Published version: archiving forbidden

Policy details

Data provided by

Abstract

We conducted a combined genome-wide association study (GWAS) of 7,481 individuals with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS Consortium. Our replication study tested 34 SNPs in 4,496 independent cases with bipolar disorder and 42,422 independent controls and found that 18 of 34 SNPs had P < 0.05, with 31 of 34 SNPs having signals with the same direction of effect (P = 3.8 x 10(-7)). An analysis of all 11,974 bipolar disorder cases and 51,792 controls confirmed genome-wide significant evidence of association for CACNA1C and identified a new intronic variant in ODZ4. We identified a pathway comprised of subunits of calcium channels enriched in bipolar disorder association intervals. Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4. Our replication results imply that increasing sample sizes in bipolar disorder will confirm many additional loci.

Published in

Links

Tools

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.

Abstract