American Chemical Society, Journal of Organic Chemistry, 17(78), p. 8853-8858, 2013
DOI: 10.1021/jo401202z
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The generation of a small and representative library of 3,5,8-trisubstituted coumarins (21 compounds, 7 families, 3 groups) is described. The library was built from the corresponding propargyl vinyl ethers and three different 1,3-dicarbonyl derivatives using a one-pot coupled domino strategy. These coumarins constitute a novel chemotype defined by the presence of a chemical handle in the pyranone ring and a varied substitution pattern adorning the aromatic ring, which includes fluorine- or oxygen-containing functionalities. © 2013 American Chemical Society. ; This research was supported by the Spanish Ministerio de Economía y Competitividad (MICINN) and the European Regional Development Fund (CTQ2011- 28417-C02-02). L.C. thanks the Spanish MEC for an FPI grant. ; Peer Reviewed