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Oxford University Press (OUP), The Journal of Clinical Endocrinology & Metabolism, 7(93), p. 2779-2785

DOI: 10.1210/jc.2008-0106

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Variation in Estrogen-Related Genes Associated with Cardiovascular Phenotypes and Circulating Estradiol, Testosterone, and Dehydroepiandrosterone Sulfate Levels

Journal article published in 2008 by Inga Peter, Alyson Kelley-Hedgepeth, Caroline S. Fox, L. Adrienne Cupples ORCID, Gordon S. Huggins, David E. Housman, Richard H. Karas, Michael E. Mendelsohn, Daniel Levy, Joanne M. Murabito
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Younger age at the onset of menopause and lower circulating levels of estrogen are risk factors for cardiovascular disease. Several studies have detected associations between variations in genes encoding estrogen receptors α (ESR1) and β (ESR2), and enzyme aromatase (CYP19A1), which regulates the estrogen to testosterone ratio, and cardiovascular phenotypes in the Framingham Heart Study. To explore potential mechanisms by which these gene variants may contribute to cardiovascular disease, we tested the hypothesis that the polymorphisms were associated with endogenous steroid hormone levels.