Published in

American Chemical Society, Journal of Proteome Research, 8(8), p. 3899-3911, 2009

DOI: 10.1021/pr900185s

Links

Tools

Export citation

Search in Google Scholar

Panorganismal Metabolic Response Modeling of an Experimental Echinostoma caproni Infection in the Mouse

Journal article published in 2009 by Jasmina Saric, Jia V. Li, Yulan Wang ORCID, Jennifer Keiser, Kirill Veselkov, Stephan Dirnhofer, Ivan K. S. Yap, Jeremy K. Nicholson, Elaine Holmes, Jürg Utzinger
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

Full text: Unavailable

Green circle
Preprint: archiving allowed
  • Must obtain written permission from Editor
  • Must not violate ACS ethical Guidelines
Upload
Orange circle
Postprint: archiving restricted
  • Must obtain written permission from Editor
  • Must not violate ACS ethical Guidelines
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The intestinal fluke Echinostoma caproni represents an ideal model parasite for investigating subpathologic changes in the murine host. We present a multicompartmental assessment of tissues and biofluids using 1H NMR spectroscopy to obtain a holistic metabolic view of the infection. Application of a novel hierarchical cluster algorithm together with conventional multivariate approaches facilitates interpretation of the systemic biochemical changes demonstrating both localized and remote effects in the host.