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Oxford University Press, Clinical Infectious Diseases, 12(54), p. 1778-1783, 2012

DOI: 10.1093/cid/cis307

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Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine

Journal article published in 2012 by Benjamin J. Cowling ORCID, Vicky J. Fang, Hiroshi Nishiura, Kwok-Hung Chan, Sophia Ng, Dennis K. M. Ip, Susan S. Chiu, Gabriel M. Leung, J. S. Malik Peiris ORCID, J. S. Malik Peiris
This paper is available in a repository.
This paper is available in a repository.

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Abstract

We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses.