Published in
Springer, Amino Acids, 4(38), p. 1269-1275, 2009
DOI: 10.1007/s00726-009-0337-5
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Role of the guanidine group in the N-terminal fragment of PTH(1–11)
Journal article published in 2009 by
Andrea Caporale 
,
Iwona Woznica,
Elisabetta Schievano,
Stefano Mammi,
Evaristo Peggion
,
Iwona Woznica,
Elisabetta Schievano,
Stefano Mammi,
Evaristo Peggion
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Abstract
A series of PTH hybrids containing a diamine [NH2(CH2) n NH2; n = 4, 5, 6] in the C-terminal position was synthesized based on the H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH2 (Har = homoarginine) template. The compounds were pharmacologically characterized at PTH1R receptors for agonist activity.