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Wiley, British Journal of Pharmacology, 10(171), p. 2568-2581, 2014

DOI: 10.1111/bph.12569

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TRP channels in the skin

Journal article published in 2014 by Balázs István Tóth ORCID, Attila Oláh, Attila Gábor Szöllősi, Tamás Bíró
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Emerging evidence suggest that transient receptor potential (TRP) ion channels not only act as "polymodal cellular sensors" found on sensory neurons but are also functionally expressed by a multitude of non-neuronal cell types. This is especially true in the skin, one of the largest organs of the body, where they apparently are deeply involved in regulating various cutaneous functions both under physiological and pathophysiological conditions. In this review, we focus on introducing the roles of several cutaneous TRP channels in the regulation of e.g. the skin barrier, skin cell proliferation and differentiation, immune functions, etc. Moreover, we also detail the putative involvement of several TRP channels in the development of certain skin diseases and define future TRP channel-targeted therapeutic opportunities.