Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.

Meurs, J. B. J. van; van Meurs, Jb B.; Pare, Guillaume; Schwartz, Sm M.; Hazra, Aditi; Tanaka, Toshiko; Vermeulen, Sh H.; Cotlarciuc, Ioana; Yuan, Xin; Malarstig, A.; Mälarstig, Anders; Bandinelli, Stefania; Bis, Jc C.; Blom, Henk; Brown, Mj J.; Chen, Constance; Chen, Yd-D.; Clarke, Rj J.; Dehghan, Abbas; Erdmann, Jeanette; Ferrucci, Luigi; Hamsten, Anders; Hofman, Albert; Hunter, Dj J.; Goel, Anuj; Johnson, Ad D.; Kathiresan, Sekar; Kampman, Ellen; Kiel, Dp P.; Kiemeney, La A. L. M.; Chambers, Jc C.; Kraft, Peter; Lindemans, Jan; McKnight, Barbara; Nelson, Cp P.; O'Donnell, Cj J.; Psaty, Bm M.; Ridker, Pm M.; Rivadeneira, Fernando; Rose, Lm M.; Seedorf, Udo; Siscovick, Ds S.; Schunkert, Heribert; Selhub, Jacob; Ueland, Pm M.; Vollenweider, Peter; Waeber, Gérard; Waterworth, Dm M.; Watkins, Hugh; den Heijer, Martin; Witteman, Jc C.; Heijer, Martin den; Jacques, Paul; Uitterlinden, Ag G.; Kooner, Js S.; Rader, Dj J.; Reilly, Muredach P.; Mooser, Vincent; Chasman, Di I.; Samani, Nj J.; Ahmadi, Kr R.

Tools

Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.

Journal article published in 2013 by J. B. J. van Meurs, Jb B. van Meurs, Guillaume Pare, Sm M. Schwartz, Aditi Hazra, Toshiko Tanaka, Sh H. Vermeulen, Ioana Cotlarciuc, Xin Yuan, A. Malarstig, Anders Mälarstig, Stefania Bandinelli, Jc C. Bis, Henk Blom, Mj J. Brown and other authors.

This paper is available in a repository.

Full text: Download

Preprint: policy unknown

Upload

Postprint: policy unknown

Upload

Published version: policy unknown

Upload

Abstract

BACKGROUND: The strong observational association between total homocysteine (tHcy) concentrations and risk of coronary artery disease (CAD) and the null associations in the homocysteine-lowering trials have prompted the need to identify genetic variants associated with homocysteine concentrations and risk of CAD. OBJECTIVE: We tested whether common genetic polymorphisms associated with variation in tHcy are also associated with CAD. DESIGN: We conducted a meta-analysis of genome-wide association studies (GWAS) on tHcy concentrations in 44,147 individuals of European descent. Polymorphisms associated with tHcy (P

Links

Tools

Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.

Abstract