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Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
Journal article published in 2013 by
J. B. J. van Meurs,
Jb B. van Meurs 
,
Guillaume Pare,
Sm M. Schwartz,
Aditi Hazra,
Toshiko Tanaka,
Sh H. Vermeulen,
Ioana Cotlarciuc,
Xin Yuan,
A. Malarstig,
Anders Mälarstig,
Stefania Bandinelli,
Jc C. Bis,
Henk Blom,
Mj J. Brown
and other authors.
,
Guillaume Pare,
Sm M. Schwartz,
Aditi Hazra,
Toshiko Tanaka,
Sh H. Vermeulen,
Ioana Cotlarciuc,
Xin Yuan,
A. Malarstig,
Anders Mälarstig,
Stefania Bandinelli,
Jc C. Bis,
Henk Blom,
Mj J. Brown
and other authors.
Abstract
BACKGROUND: The strong observational association between total homocysteine (tHcy) concentrations and risk of coronary artery disease (CAD) and the null associations in the homocysteine-lowering trials have prompted the need to identify genetic variants associated with homocysteine concentrations and risk of CAD. OBJECTIVE: We tested whether common genetic polymorphisms associated with variation in tHcy are also associated with CAD. DESIGN: We conducted a meta-analysis of genome-wide association studies (GWAS) on tHcy concentrations in 44,147 individuals of European descent. Polymorphisms associated with tHcy (P