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Springer (part of Springer Nature), Graefe's Archive for Clinical and Experimental Ophthalmology, 12(246), p. 1743-1749

DOI: 10.1007/s00417-008-0913-5

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Retinal p75 and bax overexpression is associated with retinal ganglion cells apoptosis in a rat model of glaucoma

Journal article published in 2008 by Marco Coassin, Alessandro Lambiase ORCID, Valentina Sposato, Alessandra Micera, Stefano Bonini ORCID, Luigi Aloe
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The administration of neurotrophins has been clearly demonstrated to support survival of retina cells during a variety of insults. Increased levels of neurotrophins, such as the nerve growth factor (NGF), have been found in experimental models of glaucoma. Nevertheless, loss of retinal cells does occur in the course of ocular hypertension. Therefore, this study sought to address whether timely changes in NGF and its receptors, trkA(NGFR) and p75(NTR), might explain the progression of retinal damage during experimental glaucoma.