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Springer (part of Springer Nature), Basic Research in Cardiology, 2(95), p. 84-92

DOI: 10.1007/s003950050168

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Defective suppression of the aldosterone biosynthesis during stroke permissive diet in the stroke-prone phenotype of the spontaneously hypertensive rat

Journal article published in 2000 by Iolanda Enea, Paola De Paolis, Antonio Porcellini ORCID, Ornella Piras, Carmine Savoia ORCID, Rosaria Russo, Rosangela Giliberti, Bruna Gigante, Speranza Donatella Rubattu, Giuseppe Conte, Detlev Ganten, Massimo Volpe
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Previous studies have shown that short-term high salt intake unmasks blunted plasma aldosterone suppression in stroke-prone spontaneously hypertensive rats (SHRsp). The aim of this study was to evaluate the response of aldosterone biosynthesis and production to a sustained exposure to the stroke-permissive Japanese-style diet (JD) in young stroke-prone and stroke-resistant SHRs. For this purpose, 6-week old male rats from both strains were divided into 2 dietary groups and received regular diet (SHR = 37, SHRsp = 32) or the JD and 1 % saline to drink (SHR = 34, SHRsp = 30) for 4 weeks. All measurements were carried out at the end of the dietary periods. After JD, plasma aldosterone levels were significantly decreased in SHR (from 357.8 +/- 57 to 163.3 +/- 31.5 pg/ml, p