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American Society for Microbiology, Journal of Clinical Microbiology, 8(49), p. 3026-3028, 2011

DOI: 10.1128/jcm.01102-11

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Four Independent Molecular Prion Protein Parameters for Discriminating New Cases of C, L, and H Bovine Spongiform Encephalopathy in Cattle

Journal article published in 2011 by J. P. M. Langeveld, J. H. F. Erkens, I. Rammel, J. G. Jacobs, A. Davidse, F. G. van Zijderveld, A. Bossers ORCID, H. Schildorfer
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT In anticipation of the emergence of more variants of bovine spongiform encephalopathy (BSE), a semiquantitative display of the following four independent molecular diagnostic prion parameters was designed: N terminus, proteinase K (PK) resistance, glycoprofile, and mixed population. One H BSE case, three L BSE cases, six C BSE cases, and one unusual classical BSE (C BSE) case are reported.