OBJECTIVE: To determine the effect of the warning by the Dutch Medicines Evaluation Board (CBG) in 2004 concerning SSRI use by children on the trend of SSRI utilization in the Dutch population in the period 1998-2010. DESIGN: Interrupted time series analysis. METHODS: Yearly prevalence of SSRI utilization (excluding fluoxetine) was calculated for the age categories 12-18, 19-24, 25-49, 50-64 and 65-84 years. Regression was used to determine whether the trend in SSRI utilization after 2004 changed significantly from the trend before 2004. RESULTS: Prevalence in SSRI utilization in age groups 12-18, 19-24 and 25-49 years increased in the period 1998 to 2004 and started to decline after 2004 (P