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Springer Verlag, Medicinal Chemistry Research, 5(14), p. 274-296

DOI: 10.1007/s00044-005-0139-6

Springer Verlag, Medicinal Chemistry Research, 6(14), p. 309-331

DOI: 10.1007/s00044-006-0143-5

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Synthesis and Antimuscarinic Activity of Derivatives of 2-Substituted-1,3-Dioxolanes

Journal article published in 2005 by Gabriella Marucci, Piero Angeli, Livio Brasili ORCID, Michela Buccioni, Dario Giardinà, Ugo Gulini, Alessandro Piergentili, Gianni Sagratini, Silvia Franchini ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Geometric cis, trans isomers, derivatives of 2-substituted-1,3-dioxolanes and 2-substituted-1,3-dioxanes were designed and studied as antimuscarinic agents. The synthesized compounds were evaluated as perchlorides and methiodides by functional tests with rabit vas deferens (putatvie M1), guinea-pig heart (M2) and guinea-pig ileum (M3). The effect of the replacement of a trimethylammonium group with a dimethylsulfonium in the two rings was also evalutated. Pharmacological results indicate that the 1,3-dioxane nucleus shows the highest stereoselective values on the studied receptors