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Springer Verlag, Inflammation Research, 5(59), p. 335-338

DOI: 10.1007/s00011-010-0168-6

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Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency

Journal article published in 2010 by Annalisa Marcuzzi, Giuliana Decorti, Alessandra Pontillo ORCID, Alessandro Ventura, Alberto Tommasini
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Objective The aim of this study was to evaluate, in a mouse model of mevalonate kinase deficiency (MKD), the possible link between inflammatory symptoms and serum cholesterol levels. Materials and methods Balb/c mice were treated with alendronate and bacterial muramyl dipeptide. Body temperature, interleukin-1β (IL-1β) secretion and serum cholesterol levels were measured. Results An increased production of the pro-inflammatory cytokine IL-1β (p