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Springer (part of Springer Nature), Human Genetics, 1(125), p. 105-109

DOI: 10.1007/s00439-008-0597-2

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A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility

Journal article published in 2008 by Mahamadou Diakite, Taane G. Clark, Sarah Auburn, Susana Campino, Andrew E. Fry ORCID, Angela Green, Andrew P. Morris, Anna Richardson, Muminatou Jallow, Fatou Sisay-Joof, Margaret Pinder, Dominic P. Kwiatkowski, Kirk A. Rockett
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The tumour necrosis factor (TNF) gene and other genes flanking it in the major histocompatibility complex (MHC) class III region are potentially important mediators of both immunity and pathogenesis of malaria. We investigated the association of severe malaria with eleven haplotype tagging-polymorphisms for eleven MHC class III candidate genes, including TNF, lymphotoxin alpha (LTA), allograft inflammatory factor 1 (AIF1), and HLA-B associated transcript 2 (BAT2). An analysis of 2162 case-controls demonstrated the first evidence of association between a BAT2 polymorphism (rs1046089) and severe malaria.