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Society of Nuclear Medicine, Journal of Nuclear Medicine, 4(51), p. 639-645, 2010

DOI: 10.2967/jnumed.109.072462

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68Ga-Siderophores for PET Imaging of Invasive Pulmonary Aspergillosis: Proof of Principle

Journal article published in 2010 by Milos Petrik ORCID, Hubertus Haas, Georg Dobrozemsky, Cornelia Lass-Flörl, Anna Helbok, Michael Blatzer, Hermann Dietrich, Clemens Decristoforo
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The diagnosis of invasive pulmonary aspergillosis (IPA) is difficult and lacks specificity and sensitivity. In the pathophysiology of Aspergillus fumigatus, iron plays an essential role as a nutrient during infection. A. fumigatus uses a specific and highly efficient iron uptake mechanism based on iron-complexing ferric ion Fe(III) siderophores, which are a requirement for A. fumigatus virulence. We aimed to evaluate the potential of siderophores radiolabeled with 68Ga, a positron emitter with complexing properties comparable to those of Fe(III), as a radiopharmaceutical for imaging IPA.