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Public Library of Science, PLoS ONE, 11(7), p. e47983, 2012

DOI: 10.1371/journal.pone.0047983

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In Vivo Capsular Switch in Streptococcus pneumoniae – Analysis by Whole Genome Sequencing

Journal article published in 2012 by Fen Z. Hu, Rory Eutsey, Azad Ahmed, Nelson Frazao ORCID, Evan Powell, N. Luisa Hiller, N. Luisa Hiller, Todd Hillman, Farrel J. Buchinsky, Robert Boissy, Benjamin Janto ORCID, Jennifer Kress-Bennett, Mark Longwell, Suzanne Ezzo, J. Christopher Post and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Two multidrug resistant strains of Streptococcus pneumoniae – SV35-T23 (capsular type 23F) and SV36-T3 (capsular type 3) were recovered from the nasopharynx of two adult patients during an outbreak of pneumococcal disease in a New York hospital in 1996. Both strains belonged to the pandemic lineage PMEN1 but they differed strikingly in virulence when tested in the mouse model of IP infection: as few as 1000 CFU of SV36 killed all mice within 24 hours after inoculation while SV35-T23 was avirulent.