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American Society for Microbiology, Clinical and Vaccine Immunology, 9(12), p. 1135-1138, 2005

DOI: 10.1128/cdli.12.9.1135-1138.2005

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Patients with Pulmonary Tuberculosis Develop a Strong Humoral Response against Methylated Heparin-Binding Hemagglutinin

Journal article published in 2005 by Stefania Anna Lucia Zanetti, Alessandra Bua, Giovanni Delogu ORCID, Cinzia Pusceddu, Maristella Mura, Franca Saba, Piero Pirina, Carlo Garzelli, Cono Vertuccio, Leonardo Antonio Sechi, Giovanni Fadda
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.