Dissemin is shutting down on January 1st, 2025

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Public Library of Science, PLoS ONE, 9(6), p. e24527, 2011

DOI: 10.1371/journal.pone.0024527

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Recurrent Recruitment Manoeuvres Improve Lung Mechanics and Minimize Lung Injury during Mechanical Ventilation of Healthy Mice

Journal article published in 2011 by Lucy Kathleen Reiss, Anke Kowallik, Stefan Uhlig ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Mechanical ventilation (MV) of mice is increasingly required in experimental studies, but the conditions that allow stable ventilation of mice over several hours have not yet been fully defined. In addition, most previous studies documented vital parameters and lung mechanics only incompletely. The aim of the present study was to establish experimental conditions that keep these parameters within their physiological range over a period of 6 h. For this purpose, we also examined the effects of frequent short recruitment manoeuvres (RM) in healthy mice.