Published in
Public Library of Science, PLoS ONE, 9(6), p. e24303, 2011
DOI: 10.1371/journal.pone.0024303
Links
- ORCID
- ORCID
- ORCID
- ORCID
- ORCID
- Public Library of Science
- ORCID
- [www.ncbi.nlm.nih.gov] | PDF
- [espace.library.uq.edu.au]
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
Tools
Genome-Wide Population-Based Association Study of Extremely Overweight Young Adults – The GOYA Study
,
David M. Evans,
Ellen Aagaard Nohr,
Ellen Aagaard Nohr,
Nohr Ea,
Claus Holst,
Valerie Gaborieau,
Paul Brennan,
Anette Prior Gjesing,
Anette Prior Gjesing,
Gjesing Ap,
Niels Grarup ,
Daniel R. Witte
and other authors.
Full text: Download
Abstract
Background: Thirty-two common variants associated with body mass index (BMI) have been identified in genome-wide association studies, explaining ~1.45% of BMI variation in general population cohorts. We performed a genome-wide association study in a sample of young adults enriched for extremely overweight individuals. We aimed to identify new loci associated with BMI and to ascertain whether using an extreme sampling design would identify the variants known to be associated with BMI in general populations. Methodology/Principal Findings: From two large Danish cohorts we selected all extremely overweight young men and women (n = 2,633), and equal numbers of population-based controls (n = 2,740, drawn randomly from the same populations as the extremes, representing ~212,000 individuals). We followed up novel (at the time of the study) association signals (p