Wiley, Statistics in Medicine, 20(30), p. 2504-2506, 2011
DOI: 10.1002/sim.4226
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Multivariate meta-analysis represents a promising statistical tool in several research areas. Here we provide a brief overview of the application of this methodology to combining complex multi-parameterized relationships, such as non-linear or delayed associations, in multi-site studies. The discussion focuses on the advantages over simpler univariate methods, estimation and computational issues and directions for further research.