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Rockefeller University Press, Journal of Cell Biology, 5(203), p. 757-766, 2013

DOI: 10.1083/jcb.201308173

Rockefeller University Press, Journal of Experimental Medicine, 13(210), p. 21013OIA64

DOI: 10.1084/jem.21013oia64

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Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing

Journal article published in 2013 by Andrea C. Becker, Nathalie Gasser, Susana Romao, Bruno Guhl, Milica Bajagic, Danusia Vanoaica, Urs Ziegler ORCID, Jörn Dengjel, Joachim Roesler, Janine Reichenbach, Christian Münz
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Antigen preservation for presentation is a hallmark of potent antigen-presenting cells. In this paper, we report that in human macrophages and dendritic cells, a subset of phagosomes gets coated with Atg8/LC3, a component of the molecular machinery of macroautophagy, and maintains phagocytosed antigens for prolonged presentation on major histocompatibility complex class II molecules. These Atg8/LC3-positive phagosomes are formed around the antigen with TLR2 agonists and require reactive oxygen species production by NOX2 for their generation. A deficiency in the NOX2-dependent formation of these antigen storage phagosomes could contribute to compromise antifungal immune control in chronic granulomatous disease patients.